What is Trioday (Tenofovir Disoproxil Fumarate/Lamivudine/Efavirenz) used for?

Trioday contains the combination of three anti-retroviral medications which are used to manage HIV infection in adult patients: 300 mg of Tenofovir Disoproxil Fumarate, 300 mg of Lamivudine, and 600 mg of Efavirenz.

Taking Trioday as a highly effective anti-retroviral therapy medication is intended to achieve the following treatment objectives:

• Stopping the replication of the virus in the body.
• Restoring the immune system.
• Increasing the duration and quality of life in HIV-positive patients.

How should I use Trioday (Tenofovir Disoproxil Fumarate/Lamivudine/Efavirenz)?

The medication is taken orally, once a day, at the same time each day.

To improve the tolerance of the central nervous system side effects in the first 2-4 weeks of treatment as well as in patients who keep experiencing these symptoms later on in the treatment, it is recommended to take Trioday before going to bed.

It is also recommended to take Trioday on an empty stomach. The increase in Efavirenz concentrations occurring if the medication is taken after the meal may lead to the higher incidence of adverse effects.

Reducing or splitting the daily dose is not recommended.

What are the side effects of Trioday (Tenofovir Disoproxil Fumarate/Lamivudine/Efavirenz)?

As with any treatment, the use of Trioday may cause side effects in some patients. These can be mild or severe and will not occur in all patients. If you do experience any unusual symptoms that are persistent or worrying, inform your physician as soon as possible to make sure the correct adjustments are made to your treatment.

The following side effects may occur during the treatment:

• Central nervous system: attention disorder, cerebellum coordination and balance disturbances, drowsiness, headache, tiredness.
• Digestion: decreased appetite, diarrhea, elevated liver transaminase activity, flatulence, nausea, pain and discomfort in the abdomen, vomiting.
• Laboratory test values: elevated aspartate transaminase, alanine transaminase, gamma glutamyltransferase, and amylase activity.
• Metabolism: hypophosphataemia.
• Others: dizziness, fatigue, osteonecrosis, vascular disorders.
• Psyche: abnormal dreaming, agitation, anxiety, depression, insomnia, lability.
• Respiratory system: respiratory infections.
• Skin and subcutaneous tissues: skin itching, skin rash.

Please Note

It is essential to inform the patients who are taking the highly active anti-retroviral therapy that this treatment doesn`t rule out the risks of transmitting the virus to other people through sexual contacts or blood, therefore they must keep using all the necessary precaution measures.

Frequent breaks in anti-retroviral treatment and recurrent treatment re-initiation are not recommended, as they may lead to the virus mutations, resistant to the therapy medications.

When prescribing any other medications together with Trioday, your physician has to check for possible interactions with Trioday.